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Polarean Imaging Ltd.’s technology is for research use only

Polarean 9820129Xe Hyperpolarizer

The 9820 129Xe hyperpolarizer provides a routine supply of high-purity, hyperpolarized 129Xe for gas phase magnetic resonance studies. The polarizer is typically installed near the MRI/NMR suite and processes a custom mixture of unpolarized 129Xe, N2, and 4He, into one or more doses of pure hyperpolarized 129Xe that is available for magnetic resonance studies. There is no chemical change associated with hyperpolarization-only nuclear spin alignment and cryogenic extraction of pure xenon. The hyperpolarized 129Xe is then thawed and dispensed into a container or bag. Once dispensed into an appropriate container, and maintained within a modest holding magnetic field, the polarization relaxes with a T1 of 1-2 hr.

The new generation 9820 xenon polarizer features a tunable 200W water-cooled narrowed linewidth laser, an expanded oven to accommodate substantially larger volume cells, and a 4-coil electromagnetic field configu-ration to provide uniform coverage over the oven and polarized gas plumbing.

The standard 9820 xenon polarizer configuration comes with a 1.5-L optical pumping cell, a triple-zone temperature control system, custom optics to deliver a highly uniform laser beam across the entire cell length, and a high efficiency cryogenic xenon collection system. The 9820 platform is designed with several expansion options to enhance performance and throughput as new components become available.

System Overview and Specifications

The 9820 Xenon Hyperpolarization system can be operated on site by personnel who have undergone appropriate training. Polarization levels range over 35-45% depending on the volume and throughput of produced xenon, typically at 1-3 L/h. The system operates as a Class 1 laser, and thus requires no laser protective eyewear during normal operation.

Note:

The 9820 xenon polarizer is capable of delivering 129Xe polarization levels in the range of 35-45% as a function of production rate (1-3 L/h) when operating at the peak laser power. The dashed line shows the typical 129Xe polarization leaving a 1.5-L cell whereas the color-coded lines depict the collected xenon volume using an effective solid-state xenon relaxation time of one hour.

The 9820 Xenon Hyperpolarization system is designed for research use. If the system is used to produce hyperpolarized 129Xe for hu-man inhalation, all applicable institutional and federal approvals must be obtained.

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