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Selected Literature in the Field of Hyperpolarized Gas MRI

Recent Publications

The role of hyperpolarized (129)xenon in MR imaging of pulmonary function
Ebner, Lukas; Kammerman, Jeff; Driehuys, Bastiaan; Schiebler, Mark L.; Cadman, Robert V.; Fain, Sean B., European journal of radiology. Jan 2017;86.

Hyperpolarized gas MRI in pulmonology
Kern, Agilo Luitger; Vogel-Claussen, Jens, British journal of radiology. 2018;91:1084.

New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging
Mammarappallil, Joseph G.; Rankine, Leith; Wild, Jim M.; Driehuys, Bastiaan, Journal of thoracic imaging. Mar 2019;34:2.

Safety and Tolerability

Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.
Driehuys B, et al. Radiology. 2012 Jan;262(1):279-89.

Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects.
Lutey BA, et al. Radiology. 2008 Aug;248(2):655-61.

Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease.
Shukla Y, et al. Acad Radiol. 2012 Aug;19(8):941-51.


Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis
Altes, Talissa A.; Johnson, Mac; Fidler, Meredith; Botfield, Martyn; Tustison, Nicholas J.; Leiva-Salinas, Carlos; de lange, Eduard E.; Froh, Deborah; Mugler, John P., III., Journal of cystic fibrosis. Mar 2017;16:2.

Is ventilation heterogeneity related to asthma control?
Svenningsen, Sarah; Nair, Parameswaran; Guo, Fumin; McCormack, David G.; Parraga, Grace, European respiratory journal. Aug 2016;48:2.

Hyperpolarized (129)Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests
Ebner, Lukas; He, Mu; Virgincar, Rohan S.; Heacock, Timothy; Kaushik, Suryanarayanan S.; Freemann, Matthew S.; McAdams, H. Page; Kraft, Monica; Driehuys, Bastiaan, Investigative radiology. Feb 2017;52:2.

Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma
Svenningsen, Sarah; Eddy, Rachel L.; Lim, Hui Fang; Cox, P. Gerard; Nair, Parameswaran; Parraga, Grace, American journal of respiratory and critical care medicine. Apr 2018;197:7.

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker
Horn, Felix C.; Marshall, Helen; Collier, Guilhem J.; Kay, Richard; Siddiqui, Salman; Brightling, Christopher E.; Parra-Robles, Juan; Wild, Jim M., Radiology. Sep 2017;184:3.

Noncystic Fibrosis Bronchiectasis: Regional Abnormalities and Response to Airway Clearance Therapy Using Pulmonary Functional Magnetic Resonance Imaging
Svenningsen, Sarah; Guo, Fumin; McCormack, David G.; Parraga, Grace, Academic radiology. Jan 2017;24:1.

Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients
Mahmood, K.; Ebner, L.; He, M.; Robertson, S. H.; Wang, Z.; McAdams, H. P.; Wahidi, M. M.; Shofer, S. L.; Huang, Y. T.; Driehuys, B., American journal of transplantation. Jul 2017;17:7.

Hyperpolarised 129Xe MRI to monitor treatment response in children with cystic fibrosis
Jonathan H. RaymentMarcus J CouchMarcus J CouchNancy McDonaldShow all 7 authorsFelix Ratjen, European Respiratory Journal. Feb 2019.

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma
Mummy, D. G., J Allergy Clin Immunol. 2017.

129Xe MRI detects ventilation deficits in pediatric stem-cell transplant patients unable to perform spirometry
Laura L. Walkup, Kasiani Myers, Javier El-Bietar, Adam Nelson, Matthew M. Willmering, Michael Grimley, Stella M. Davies, Christopher Towe, Jason C. Woods, European respiratory journal. Mar 2019.

Hyperpolarized 3He Ventilation Defects Used to Predict Pulmonary Exacerbations in Mild to Moderate Chronic Obstructive Pulmonary Disease
Kirby, Miranda, Radiology. 2014.

Hyperpolarized 3He pulmonary functional magnetic resonance imaging prior to radiation therapy.
Mathew L, et al. Med Phys. 2012 Jul;39(7):4284-90.

Hyperpolarized 3He Magnetic Resonance Imaging: Comparison with Four-dimensional X-ray Computed Tomography Imaging in Lung Cancer.
Mathew L, et al. Acad Radiol. 2012 Dec;19(12):1546-53.

Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized 3He MR imaging.
Kirby M, et al. Radiology. 2011 Oct;261(1):283-92.

Hyperpolarized 3He and 129Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease.
Kirby M, et al. Radiology. 2012 Nov;265(2):600-10.

Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation.
Kirby M, et al. J Magn Reson Imaging. 2012 Nov 2.

Hyperpolarized 3He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease.
Mathew L, et al. Eur J Radiol. 2011 Jul;79(1):140-6.

In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry.
Quirk JD, et al. Radiology. 2011 Sep;260(3):866-74.

Cystic Fibrosis

Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function.
Bannier E, et al. Radiology. 2010 Apr;255(1):225-32.

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients.
Sun Y, et al. J Magn Reson Imaging. 2011 Nov;34(5):1206-11.

Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis.
Kirby M, et al. Acad Radiol. 2011 Aug;18(8):1006-13.


Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging.
de Lange EE, et al. Radiology. 2009 Feb;250(2):567-75.

Regional pulmonary response to a methacholine challenge using hyperpolarized 3He magnetic resonance imaging.
Costella S, et al. Respirology. 2012 Nov;17(8):1237-46.

Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI.
Aysola R, et al. J Magn Reson Imaging. 2010 Dec;32(6):1379-87.

Gas Exchange Imaging Methodologies

Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.
Driehuys B, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18278-83.

A short-breath-hold technique for lung pO2 mapping with 3He MRI.
Miller GW, et al. Magn Reson Med. 2010 Jan;63(1):127-36.

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129.
Mugler JP 3rd, et al. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21707-12.

Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.
Kaushik SS, et al. J Appl Physiol 2013;115(6):850-860.

Regional Mapping of Gas Uptake by Blood and Tissue in the Human Lung Using Hyperpolarized Xenon-129 MRI.
Qing K, et al. J Magn Reson Imaging 2014;39(2):346-359.