Polarean’s technology is for research use only

Selected Literature in the Field of Hyperpolarized Gas MRI

Recent Review Articles

Pulmonary Functional Imaging Using Hyperpolarized Noble Gas MRI: Six Years of Start-up Experience at a Single Site.
Kirby M, et al. Acad Radiol 2013;20(11):1344-1356.

Hyperpolarized 129Xe MRI of the human lung.
Mugler JP, et al. J Magn Reson Imaging 2013;37(2):313-331.

Imaging of Lung Function Using Hyperpolarized Helium-3 Magnetic Resonance Imaging: Review of Current and Emerging Translational Methods and Applications.
Fain S, et al. J Magn Reson Imaging 2010;32(6):1398-1408.

Safety and Tolerability

Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.
Driehuys B, et al. Radiology. 2012 Jan;262(1):279-89.

Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects.
Lutey BA, et al. Radiology. 2008 Aug;248(2):655-61.

Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease.
Shukla Y, et al. Acad Radiol. 2012 Aug;19(8):941-51.

Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized 3He MR imaging.
Kirby M, et al. Radiology. 2011 Oct;261(1):283-92.

Hyperpolarized 3He and 129Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease.
Kirby M, et al. Radiology. 2012 Nov;265(2):600-10.

Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation.
Kirby M, et al. J Magn Reson Imaging. 2012 Nov 2.

Hyperpolarized 3He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease.
Mathew L, et al. Eur J Radiol. 2011 Jul;79(1):140-6.

In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry.
Quirk JD, et al. Radiology. 2011 Sep;260(3):866-74.

Cystic Fibrosis

Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function.
Bannier E, et al. Radiology. 2010 Apr;255(1):225-32.

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients.
Sun Y, et al. J Magn Reson Imaging. 2011 Nov;34(5):1206-11.

Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis.
Kirby M, et al. Acad Radiol. 2011 Aug;18(8):1006-13.


Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging.
de Lange EE, et al. Radiology. 2009 Feb;250(2):567-75.

Regional pulmonary response to a methacholine challenge using hyperpolarized 3He magnetic resonance imaging.
Costella S, et al. Respirology. 2012 Nov;17(8):1237-46.

Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI.
Aysola R, et al. J Magn Reson Imaging. 2010 Dec;32(6):1379-87.

Chronic Obstructive Pulmonary Disease

Hyperpolarized 3He pulmonary functional magnetic resonance imaging prior to radiation therapy.
Mathew L, et al. Med Phys. 2012 Jul;39(7):4284-90.

Hyperpolarized 3He Magnetic Resonance Imaging: Comparison with Four-dimensional X-ray Computed Tomography Imaging in Lung Cancer.
Mathew L, et al. Acad Radiol. 2012 Dec;19(12):1546-53.

Gas Exchange Imaging Methodologies

Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.
Driehuys B, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18278-83.

A short-breath-hold technique for lung pO2 mapping with 3He MRI.
Miller GW, et al. Magn Reson Med. 2010 Jan;63(1):127-36.

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129.
Mugler JP 3rd, et al. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21707-12.

Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.
Kaushik SS, et al. J Appl Physiol 2013;115(6):850-860.

Regional Mapping of Gas Uptake by Blood and Tissue in the Human Lung Using Hyperpolarized Xenon-129 MRI.
Qing K, et al. J Magn Reson Imaging 2014;39(2):346-359.